Sentence examples for barrier dysfunction has been from inspiring English sources
A barrier dysfunction has been characterized in patients suffering from IBD that leads to enhanced intestinal permeability [ 102].
Intestinal barrier dysfunction has been found to play a pathogenic role not only in IBD, but also in IBS [ 1].
Vascular barrier dysfunction has been shown to play a critical role in the complex pathogenesis of AKI [ 46].
This is an important area of investigation since blood brain barrier dysfunction has been documented in other mitochondrial DNA disorders, including mitochondrial neurogastrointestinal encephalopathy (MNGIE) (Szigeti et al., 2004).
Although it is well known that hypoxia is the most potent regulator of VEGF gene expression and protein production [ 35], an oxygen-independent up-regulation of VEGF and vascular barrier dysfunction has been observed [ 36].
A number of genetically modified mouse models with deranged junctional complexes and barrier dysfunction have been reported, for which a subset develop spontaneous or inducible inflammatory pathology and provide useful preclinical models of colitis and CAC (Hermiston and Gordon, 1995; Laukoetter et al., 2007; Rudolph et al., 1995; Saitou et al., 2000; Smalley-Freed et al., 2010).
Interestingly, microvascular blood brain barrier (BBB) dysfunction has been reported in early stages of AD [ 4].
In the gastrointestinal (GI) tract, enteric glia have been shown to play important roles in the formation and maintenance of the intestinal epithelial barrier, neurotransmission and immune response, and their dysfunction has been linked to inflammatory GI pathology (Bush et al., 1998; Cabarrocas et al., 2003; Gulbransen and Sharkey, 2012; Neunlist et al., 2012).
Cerebrovascular dysfunction has been considered to cause impairment of cerebral amyloid-β peptide (Aβ) clearance across the blood-brain barrier (BBB).
