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Similar to female GSCs, BALL is required to maintain self-renewal of male GSCs, suggesting a tissue independent requirement of BALL for self-renewal of germline stem cells.
A replacement ball is required already.
We have recently shown that BALL is required to sustain self-renewal of niche-controlled stem cells (Herzig et al., 2014).
Hence, we used the bam Δ86 mutant cells to address whether BALL is required for a GSC-like organization of the nucleolus.
Our study shows that the VRK-1 kinase BALL is required for self-renewal of germline stem cells in Drosophila, including the symmetrically amplifying PGCs of larvae and both male and female GSCs.
To see whether BALL is required for maintenance of expanded nucleoli in cells that normally differentiate, we asked whether the nucleoli of follicle cells, which increase their nucleoli during endoreduplication, are affected by the absence of BALL.
Similar(51)
First of all, though, possession of the ball was required.
At the bare minimum, six stumps, four bails, two cricket bats and a ball are required.
To decrease the surface roughness of the coatings, repeated treatments using small balls are required.
By both rules, a foul ball did not count as a strike, a hit batsman counted only as a ball, and seven balls were required for a walk.
Here we report that the BALL kinase is required to maintain the proliferative potential of NBs and that this function of BALL is a prerequisite for self-renewal.
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