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However, an alternative hypothesis is that balancing selection has maintained most of the MHC variation across the species complex.
The evolutionary history of ABO indicates that balancing selection has maintained a polymorphism at this locus for many millions of years, and hence that these variants are important to the fitness of humans and other primates.
Our findings, from calculating the ratio of non-synonymous to synonymous substitutions, indicate that balancing selection has maintained genetic variation of peptide-binding residues at the DQB locus of the Japanese black bear.
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For 3.8 billion years natural selection has maintained favorable adaptations and weeded out unworkable ones.
If balancing selection has worked to maintain functional binding events during Drosophila evolution, then one would expect to find selective constraint on the nucleotide sequence within binding intervals.
Combined with the evidence of a high level of polymorphism at this locus, this result supports the hypothesis that balancing selection has acted to maintain polymorphisms at this locus [ 4].
An estimate for the minimum age of 2Rj was derived under a model that assumes a unique origin for the inversion, complete genetic isolation of alternative arrangements, and balancing selection which has maintained the inversion at its present frequency since immediately following its origin [30].
Balancing selection has been suggested to maintain variation at several other innate immune genetic loci, such as CD209L cell-surface receptor [ 36] and the killer immunoglobulin-like receptors (KIR) [ 37], and at loci involved in reproduction, such as zonadhesin [ 38].
This type of balancing selection has previously been implicated in maintaining diversity in the context of host parasite interactions [ 25].
Venezuela has maintained a positive trade balance.
Loci experiencing balancing selection (which maintains variation) should have larger amounts of polymorphism within populations and smaller amounts among populations than neutral loci (assuming selection pressures are similar between populations), whereas the opposite pattern is expected for loci experiencing directional selection [ 27].
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