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Our data indicate that long-standing balancing selection has characterized the evolutionary history of non-HLA genes located in the xMHC but only a minority of alleles with opposite risk profile can be regarded as targets of natural selection in human populations.
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In other cases, a loss of balancing selection has been observed at MHC [ 15].
We aimed at testing the hypothesis whereby balancing selection has shaped the frequency of opposite risk alleles.
Of course, the fact that balancing selection alone cannot explain the pattern of divergence in atp9 does not rule out the possibility that balancing selection has been acting on atp9 and other mitochondrial genes in Silene.
Whether balancing selection has been a major force in the human genome is disputed, and distinguishing signatures of balancing selection from neutral variation is difficult without a clear prior hypothesis concerning the potential mechanism of balancing selection in a given candidate gene [ 40].
Balancing selection has also been used to explain differences between allelic forms that confer different behaviors.
Balancing selection has traditionally been considered to have acted less frequently on human populations, and the number of reported cases is smaller in comparison to positive selection.
This type of balancing selection has previously been implicated in maintaining diversity in the context of host parasite interactions [ 25].
However, an alternative hypothesis is that balancing selection has maintained most of the MHC variation across the species complex.
One possible explanation for this heterogeneity could be the maintenance of balancing selection and/or historical balancing selection having led to a higher retention of diversity at a subset of genomic regions.
But soon he and his transition team may look back on this phase as luxuriantly languid, a fleeting chance for "deliberate haste," as Mr. Obama has characterized the pace of his cabinet selection process.
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