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In support of the biological significance of the contrasting population structures observed, balancing selection has been detected in all of the merozoite antigens [51], [52], [53], [54], [55] whereas for the non-merozoite antigens, balancing selection was detected in trap and pfs48/45 [56], [57] but not in csp [57] and lsa1 [58] (glurp has not been investigated).
In other cases, a loss of balancing selection has been observed at MHC [ 15].
Of course, the fact that balancing selection alone cannot explain the pattern of divergence in atp9 does not rule out the possibility that balancing selection has been acting on atp9 and other mitochondrial genes in Silene.
Whether balancing selection has been a major force in the human genome is disputed, and distinguishing signatures of balancing selection from neutral variation is difficult without a clear prior hypothesis concerning the potential mechanism of balancing selection in a given candidate gene [ 40].
Balancing selection has been largely proposed as one of the main mechanisms responsible for the maintenance of polymorphisms in populations (Kojima 1971).
Balancing selection has been suggested to maintain variation at several other innate immune genetic loci, such as CD209L cell-surface receptor [ 36] and the killer immunoglobulin-like receptors (KIR) [ 37], and at loci involved in reproduction, such as zonadhesin [ 38].
Similar(52)
Moreover MEFV also shows an excess of intermediate variants in one of the neutrality tests in Europeans, and signatures of balancing selection have been previously reported [ 12, 13].
Evidence for balancing selection has also been found in Arabidopsis lyrata[ 42, 43], and differences in the types of selection at the same R-genes have been observed between Arabidopsis thaliana and A. lyrata.
Other studies have shown that genome-wide testing for balancing selection has thus far been fruitless, leading to suggestions that it is either rare or hard to find (Bubb et al. 2006).
Both directional [ 22, 25] and balancing [ 55, 56] selection have been shown to operate on variation in male colour patterns in the guppy, and could therefore function to influence visual variation if a similar linkage exists in the guppy.
One of the most interesting examples is probably that of UGT2B4, which has been strongly associated with increased risk of breast cancer in Nigerians and, to a lesser extent, African Americans, and signatures of selection (balancing selection or recent positive selection) have been found in the upstream portion of the gene (Sun et al. 2011).
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Justyna Jupowicz-Kozak
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