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In this study, we examined whether balancing selection can explain the high rate of nonsynonymous polymorphism observed in a small set of genes exhibiting a disproportionately large excess of nonsynonymous polymorphism, as this could obscure evidence of positive selection in S. cerevisiae.
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However, balancing selections can explain establishing such clines, because the combination of gene-by-environment interaction and balancing selection independently determine the equilibrium morph frequency in each local population.
There is a poor empirical understanding about whether a balance between different forms of selection can explain mixed breeding systems (Goodwillie et al., 2005; Escobar et al., 2008; Chelo and Teotonio, 2013).
Female criteria for partner selection can explain such a result.
As we have shown, germline selection can explain these mutation clusters.
Endemic human pathogens are subject to strong immune selection, and interrogation of pathogen genome variation for signatures of balancing selection can identify important target antigens.
Balancing selection can act to maintain functionally important polymorphisms in a population.
Hidden population structure and balancing selection can also cause genetic patterns similar to a bottleneck.
It is tempting to speculate that the traces of balancing selection can be linked to the BB genome.
Rather, a mutation-selection balance can explain the evolutionary maintenance of such genes and is supported by the underrepresentation on the lagging strand of highly expressed genes and essential genes.
Therefore, it is unlikely that selection bias can explain the observed associations.
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