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This CRISPRi-guided balancing of expression of MVA pathway genes led to enhanced production of -α-bisabolol (C15) and lycopene (C40) and alleviation of cell growth inhibition that may be caused by expression of multiple enzymes or production of toxic intermediate metabolites in the MVA pathway.
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Cathepsins exhibit tissue and stage specific expression pattern which is fine-tuned by a delicate balance of expression, compartmentalization, zymogen activation, inhibition by protein inhibitors and degradation.
Furthermore, a more advantageous balance of expression levels between the partial cascade enzymes was achieved via engineering of the ribosome binding site.
It is possible that the balance of expression of FcγRIIb and FcεRI by alveolar macrophages determines a pro-inflammatory versus anti-inflammatory role of these cells.
BER proteins require a finely tuned balance of expression to ensure complete repair of many mutagenic or genome destabilizing base lesions [24], [46], [51] [54].
Interestingly, the overall balance of expression of retinoid-related HVC markers suggests a general suppression of growth- and development-related pathways and an enhancement of stabilizing cell adhesion specializations and neuronal differentiation.
As for many other transcription factors, HES1 is a point of integration between and among different signal transduction pathways, and its balance of expression determines fundamental cell decisions, such as whether or not to start a differentiation program.
Most of these virulence genes are organized within particular regions of the genome, termed pathogenicity islands, which are regulated by complex regulatory networks: the delicate balance of expression of many genes acting at the correct time in the correct location [3], [4].
In HCC, this balance of expression is lost.
This suggests that a delicate balance of expression exists across the RXR gene network.
The balance of expression of the Bcl-2 family is important for the modulation of apoptosis in cancer cells.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com