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Interferon beta balances the expression of pro- and anti-inflammatory agents in the brain, and reduces the number of inflammatory cells that cross the blood brain barrier.
Our data are consistent with D. serrata male dosage compensation via hyperexpression of the X chromosome to a level that balances the expression of autosomal genes (fig. 4 A).
This should include the replacement of the GAL1-promotor, that was used for the expression of PRK in this study, by a promotor that is compatible with fast growth at high glucose concentrations and that further balances the expression of PRK and Rubisco.
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On the basis of force balance, the expression of vertical apparent shear stress was obtained.
The anti-apoptotic effect of 5-HMF was further evidenced by balancing the expression of Bcl-2 family members.
Human hemoglobin has previously been synthesized in yeast, however the challenge is to balance the expression of the two different globin subunits, as well as the supply of the prosthetic heme required for obtaining the active hemoglobin (α2β2).
Disaccharide analysis of the engineered HS showed a substantial increase in N-sulfo groups, but did not show a pattern consistent with pharmacological heparin, suggesting that further balancing the expression of transgenes with the expression levels of endogenous enzymes involved in HS/heparin biosynthesis might be necessary.
These tools must be able to simultaneously evaluate the effectiveness of individual mutant proteins while balancing the expression of transporters and multiple pathway genes.
This suggests that complete dosage compensation is required to balance the expression of key gene networks throughout the genome of M. sexta.
Animals adapt different dosage compensation mechanisms to balance the expression of sex chromosome genes between the two sexes and to balance the expression between sex chromosomal genes and autosomal genes [ 26, 60].
We interpret this result as evidence of some regulatory mechanism that tries to balance the expression of genes off the aneuploid chromosome with their interaction partners that are on this chromosome.
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