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Jason Todd, a neurologist from North Carolina, said, "Honestly, it looks like the best treatment, in terms of balancing effectiveness and side effects, is placebo".
It should be remembered that to be commercially viable drugs need to balance effectiveness with safety and there is little incentive to find the minimally effective dose.
In this paper test results are shown for sudden imbalance, and the computational time requirements and balancing effectiveness for the various approaches are compared.
Evidently, any screen of this scale must balance effectiveness against cost.
The treatment that best balanced cooling effectiveness against water usage was 1.3 L/min: although ≥4.5 L/min reduced respiration rate relative to baseline by 4 more breaths/min than 1.3 L/min did (−13 vs. −9 breaths/min, respectively), each additional liter of water decreased this measure by only ≤0.1 breaths/min (≤1% of the total reduction achieved using 1.3 L/min).
Ease of use and tolerance, however, need to be balanced against effectiveness and accuracy.
In mixed urban and rural settings, commissioners will still be expected to deliver a comprehensive stroke service, which extends beyond acute care to address life after stroke, and which balances effectiveness and efficiency with the availability of service supports, including human and other resources.
Risk factors for the development of chronic low back pain were identified from the literature to provide targets for treatment, essential components of a CB intervention were considered using the CB treatment model, and the optimal delivery method was used to balance clinical effectiveness and cost-effectiveness within primary care.
One of the ads is misleading because it fails to provide any risk information relating to side effects to balance the effectiveness claims, the F.D.A. wrote.
The conservative C-section policy and the interpretation of quality largely as clinical effectiveness also illustrates the potential inherent trade-offs in balancing clinical effectiveness, patient safety, and patient experiences when improving quality.
Injection protocols were designed for application in Atlantic bottlenose dolphins (Tursiops truncatus) to balance vaccine effectiveness with clinical utility.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com