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Furthermore, a more advantageous balance of expression levels between the partial cascade enzymes was achieved via engineering of the ribosome binding site.
Cathepsins exhibit tissue and stage specific expression pattern which is fine-tuned by a delicate balance of expression, compartmentalization, zymogen activation, inhibition by protein inhibitors and degradation.
BER proteins require a finely tuned balance of expression to ensure complete repair of many mutagenic or genome destabilizing base lesions [24], [46], [51] [54].
It is possible that the balance of expression of FcγRIIb and FcεRI by alveolar macrophages determines a pro-inflammatory versus anti-inflammatory role of these cells.
As for many other transcription factors, HES1 is a point of integration between and among different signal transduction pathways, and its balance of expression determines fundamental cell decisions, such as whether or not to start a differentiation program.
Interestingly, the overall balance of expression of retinoid-related HVC markers suggests a general suppression of growth- and development-related pathways and an enhancement of stabilizing cell adhesion specializations and neuronal differentiation.
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This CRISPRi-guided balancing of expression of MVA pathway genes led to enhanced production of -α-bisabolol (C15) and lycopene (C40) and alleviation of cell growth inhibition that may be caused by expression of multiple enzymes or production of toxic intermediate metabolites in the MVA pathway.
Zammarchi et al developed an ASO targeting a splicing enhancer site that was able to shift the balance of STAT3 expression to favor STAT3β expression.
The company said the goal was to balance freedom of expression with compliance with local laws.
The fundamental question Starmer has to decide is how to balance freedom of expression against the restrictions on free speech laid down by parliament.
Twitter has said that its goal is to balance freedom of expression with compliance with local laws.
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