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Regulation of NK cell activity requires a tight balance between activating and inhibitory signals, which is mediated by distinct classes of receptors on the cell surface.
It is considered that the balance between activating and inhibitory FcγRs is a mechanism for terminating activation responses in arthritis [ 23].
NK cell triggering results from a balance between activating and inhibitory signals.
A delicate balance between activating and inhibitory signals emanating from the FcγRs characterizes a normal immune response.
In the postsynapse, the regulation of nNOS is dependent on the balance between activating and inactivating phosphorylation.
The balance between activating and inhibitory receptors determines the outcome of the NK cell-target cell encounter.
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Its regulation relies on the delicate balance between activating kinases and suppressing phosphatases and is still not very well understood.
We know the mechanisms involved in the synthesis of hepcidin and, under physiological conditions, there is a balance between activating signals and inhibitory signals that regulate its synthesis.
The signaling required to activate NK cells is a balance between activating receptors (e.g. NKG2D, NKp30, and NKp46) and inhibitory receptors (e.g., killer cell immunoglobulin like receptors (KIRs), NKG2A).
The cytolytic activity of NK cells is regulated by a fine balance of activating and inhibitory NK cell receptors.
A fine balance between inhibitory and activating receptors tightly regulates NK cell activation.
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