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Once a glacier begins retreating, it may fall into disequilibrium and be unable to find mass balance (accumulation versus melting rate) at any size.
Hence, when treating an ICU patient with vancomycin, physicians should balance accumulation with subtherapeutic level of vancomycin; though this can be particularly challenging in patients with kidney dysfunction, as vancomycin clearance is mainly related to kidney function and such patients are at a higher risk of nephrotoxicity (compared to those with normal kidney function) [ 14, 15].
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Myocardial infarction involves balanced accumulation of monocytes and macrophages in tissue.
GB has been shown in vitro (i) to stabilize membranes of the oxygen evolving photosystem II complex and (ii) to accumulate in the cytoplasm to balance the accumulation of solutes and ions in the vacuole during osmotic adjustment (Papageorgiou and Murata, 1995).
After failure of this balance, ROS accumulation occurs.
The annual net C balance (net accumulation) provides a second metric to compare models of HWP in North America.
KCC in HbF cells has a higher total capacity, but when measured at the ambient PO2 of fetal blood it would be similar in magnitude to that in fully oxygenated HbA cells, and about that required to balance K+ accumulation via the Na+/K+ pump.
Both genetic and environmental factors dictate the rate of tissue regeneration and the balance between accumulation and removal of cellular damage.
In cancer cells, this metabolic shift counteracts the Warburg effect, a defining characteristic of many malignant cells, resulting in altered redox balance and accumulation of oxidative DNA damage that inhibits cell proliferation and induces a senescence-like phenotype.
Cisplatin increases the production of free oxygen radicals and decreases the antioxidants, thus resulting in the deterioration of the oxidant/antioxidant balance and accumulation of reactive oxygen radicals in tissues [ 27].
A better understanding of the molecular mechanisms that are involved in the pathogenesis of the disease as well as those that regulate the local balance between accumulation of extracellular matrix and their degradation will be critical to set the MMPs in their exact place.
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CEO of Professional Science Editing for Scientists @ prosciediting.com