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Nevertheless, there is consistent opinion that during patient controlled analgesia (PCA) patients balance acceptable pain relief against unacceptable side effects.
In general, both the FDA and EMA have recognized some uncertainties relating to safety and efficacy with the novel agents; however, the FDA considered the risk to benefit balance acceptable for specific issues to be addressed with post-marketing trials, whereas the EMA demanded that further data be obtained prior to licensing.
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Specifically, the department should "urgently review the proper balance between acceptable risks and expected outcomes in high risk, high threat areas". The "acceptable" threat tolerance may become close to zero.
Experience shows that some societies are much more decent than others, and that in fits and starts, cruelty, oppression and discrimination have become on balance less acceptable over time.
Any consistent set of units for the quantities in this mass balance is acceptable (Cooney 1998).
The rate of unnecessary laparotomies is still high: to balance an acceptable positive laparotomy rate with minimal delayed or missed diagnoses, the clinician must take into account all the available historical and physical findings, laboratory data, and appropriate imaging method.
Although the sample of schoolchildren came from varying academic abilities, socioeconomic background and the gender balance was acceptable, this study was conducted in an urban area.
A significance cutoff within about an order of magnitude of 10−5 is inferred to balance an acceptable false positive rate with sufficient power to detect true associations.
In the franchisee recruitment process, MSI and PSI work to strike the right balance between acceptable standards and room for improvement.
The INR targeted for anticoagulation reversal patients is higher than that targeted for bleeding patients (INR of 1.2) due to the need to balance an acceptable risk of bleeding with sufficient prevention of thromboembolism.
Is a specific level of (positive) fluid balance an acceptable trigger for starting RRT? Otherwise, should we have in mind a specific target of negative fluid balance, and should RRT be started as soon as possible in order to reach such a goal?
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com