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In vitro BADGE exposure enhances differentiation of MSCs into adipocytes.
Future in vivo studies should also test the effects of BADGE exposure at biologically realistic concentrations.
Spearman rank correlations between badge exposure measures and salivary measures were small to moderate (0.3 at maximum).
BADGE exposure caused developmental toxicity during gestation and lactation in rats (Hyoung et al. 2007) and toxicity in cell culture (Ramilo et al. 2006).
BADGE exposure elicited an adipogenic gene expression profile, and its ability to induce adipogenesis and the expression of adipogenic genes was not blocked by known PPARγ antagonists.
Therefore, BADGE exposure does not promote or facilitate adipogenic differentiation to the detriment of osteogenic differentiation in MSCs, and we therefore infer that BADGE probably acts through a different mechanism than does ROSI or other PPARγ activators such as TBT.
Similar(54)
In some instances, the personal badges captured only exposure outside of the workplace, as some study participants did not work during the 24 hours prior to the health examination.
To protect her unborn baby, she wore a special low exposure radiation badge on her tummy while pregnant and minimised her exposure to x-rays and gamma rays, as well as avoiding volatile solvents.
Since 1966, individual film badge measurements of gamma exposure were recorded for a majority of underground workers.
Film badges used to measure exposure to radioactivity indicated that no observers at N-10,000 had been exposed to more than 0.1 roentgens, but the shelter was evacuated before the radioactive cloud could reach it.
Using objective measures such as badges to monitor actual exposure is likely not feasible in the school setting but has potential in some studies.
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