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Diminished giant trophoblast cells, diminished placental perfusion and bad pregnancy outcomes were observed in CBA/J x DBA/2 mice [5], [6].
Our observations are in agreement with these studies as we described an important role for inflammation (in particular complement activation) and thrombosis in the bad pregnancy outcomes in the CBA/J x DBA/2 model [5], [6].
DBA/J mated CBA/J females spontaneously develop many features of human PE (primigravidity, albuminuria, endotheliosis, increased sensitivity to angiotensin II and increased plasma leptin levels) that correlates with bad pregnancy outcomes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com