Sentence examples for bad pathway from inspiring English sources

In an attempt to explore the biological significance of the network connections suggested by GIENA, we examined the details of the regulation of BAD pathway.

Thus, the use of the competition profile revealed sub-components of the BAD pathway that are involved in maintaining tight molecular balance of signaling, changes that could not be detected by individual gene expression alone.

The BAD pathway is ranked relatively highly in the results from GSA, (eighth ranked pathway with q around 0.02), while it is assigned 5-fold more significant q-value s by GIENA (0.004) based on the competition profile.

Specifically, these observations provide a testable hypothesis that a subset of competing interactions within the BAD pathway is critical to the changes seen as a result of p53 status.

That is, pathway score is equal to ∑ w i x i, a weighted average expression among the BAD pathway genes, where x i represents gene i expression level, w i is the corresponding weight (loading coefficient) with ∑ w 2 i =1, and the w i values maximise the variance of ∑ w i x i.

Figure  3 shows a simplified BAD pathway that includes: two genes that show dysregulation with respect to individual gene expression in the p53 datasets (e.g. BAX and PIK3CA), three pairs of genes that show dysregulated interactions (CSF2RB-IL3RA, IL3RA-PRKACG, and PRKACG-PRKAR2A), and additional genes that connect them with BAD as the hub.

Most proteome changes, in particular upon 40 Gy IR, affected mitogenic signaling events controlling cell survival (MKK3/6-p38-MK2 pathway, MEK-ERK pathway, LKB-AMPK pathway, PKC-Bad pathway).

BAD-pathway expression and BAD protein phosphorylation were evaluated in patient samples and cell lines as determinants of chemosensitivity and/or clinical outcome and as therapeutic targets.Induced in vitro OVCA cisplatin resistance was associated with BAD-pathway expression (P < 0.001).

A 47-gene BAD-pathway score was associated with in vitro phosphorylated BAD levels and with survival in 142 patients with advanced-stage (III/IV) serous OVCA.

Integration of BAD-phosphorylation or BAD-pathway score with OVCA surgical cytoreductive status was significantly associated with overall survival by log-rank test (P = 0.004 and P < 0.0001, respectively).The BAD apoptosis pathway influences OVCA chemosensitivity and overall survival, likely via modulation of BAD phosphorylation.

In a further sign of the biofuels debate heating up, European bioethanol producers have also sent a letter to the EU's energy and climate action Commissioners, seen by EurActiv, calling for Brussels to introduce ILUC factors that distinguish between "good and bad biofuel pathways".