Exact(2)
Hence, it is plausible that during the induction of apoptosis by hUCBSC, mitochondrial upregulated Bax and Bad induce the activation of caspase-9 in glioma cells which ultimately triggers the activation of caspase-3, ultimately leading to the apoptotic death by the cleavage of PARP.
It is hypothesized that the BH3-only proteins, such as Bim, Bid, Puma, Noxa and Bad induce the activation of Bax and Bak, either directly or indirectly by inactivating the prosurvival Bcl-2 proteins.
Similar(58)
In animal studies, ferulic acid was found to attenuate the decrease in parvalbumin expression and prevent the decrease in Akt phosphorylation of Bad induced by focal cerebral ischemic injury.
But this in vitro finding was challenged with recent reports that phosphorylation of BAD is essential for the survival of cancer stem cells, whereas ectopic expression of a phosphorylation-deficient mutant BAD induced apoptosis in cancer stem cells (Sastry et al., 2014).
It's not clear why bad singers -- the ones who get a career bounce after being vituperated on "American Idol" -- can inspire maternal feelings or glee, while bad comics induce nausea and sorrow.
The coughing spasms won't kill you but can continue for months, and in bad cases induce vomiting or even break a rib.
Downregulation and phosphorylation of Bcl-2 as well as upregulation of Bad may induce depolarization of mitochondria and subsequent translocation of cytochrome c into the cytosol.
(PMID 10579309) Bad phosphorylation induced by survival factors leads to its preferential binding to 14-3-3 14-3-3 14-3-3on of the deand-inducing function of Bad.
In contrast, the next sentence not only points to a temporal relationship in which phosphorylation happens before the interaction but also describes a causal relation (i.e. how the interaction is a consequence of the phosphorylation): Bad phosphorylation induced by survival factors leads to its preferential binding to 14-3-3 14-3-3 14-3-3on of the deand-inducing function of Bad.
Deficits are not of the "good" kind (planned to produce use values, and self-dissolving through qualitative development), but of the "bad" kind (induced by real stagnation or saving finance).
That night, in the endless click-trance that bad news induces on the internet, I was passing through sites from different cities' occupations when I landed on an effort called Occupy the Boardroom.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com