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The disorder region can be defined better as a hard work for drug design than as a bad docking site for selection in our known.
Therefore, the disorder region should be defined as a hard work for drug design and not a bad docking site for selection.
But some references [ 41, 42] indicate that the interaction with the disorder region might cause lower side effect than with the widespread domain; thus, the disorder region cannot be defined as a bad docking site for selection.
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ABT-737 mimics the BH3-only protein, Bad, by docking to the hydrophobic groove of antiapoptotic proteins, thereby disabling their capacity to antagonize the actions of proapoptotic proteins.
First, the bad: the dock for the iPhone 3G isn't included with the phone itself.
In some countries, academic points can even be docked for bad behaviour.
With two points docked for bad behaviour and the team knocked out of Champions League qualification after an embarrassing 5-0 capitolation to Wislaw Krakow, the side drew 0-0 with arch-rivals Bnei Sakhnin in the opening game of the season.
Already, even without a drop of oil in the oyster beds, the ripple effects have been felt by the fishermen who have been docked (the bad weather on Saturday contributed to that), to the marinas losing business, to the processors and distributors, all of whom have only begun to recover from Hurricane Katrina.
Docking port?
Finally, the weaknesses of the scoring functions were described to be responsible for the docking bad performance of some programs.
In reality this penalty wasn't so bad, since those who had their checks docked for working received higher benefits later on.
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