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As before, the pharmacophore filtering creates a natural cut-off point (shown by the dashed line in Figure 7) for separating good compounds from bad compounds.
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Both made bad decisions, compounded by bad timing, as the telecoms bubble inflated in the late 1990s.
Bad luck compounding imprudent decisions, his career was over, a half-dozen years after his showdown with James.
Speaking to reporters in Dushanbe, the capital, in late September, she said the failed harvest this year had been preceded by two years of bad harvests, compounded by "an incredible rise in the level of poverty in the last 10 years".
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Microbes, he argued, don't just happen to spoil food when they gorge on it; they have evolved to make it unappetizing to large animals as fast as possible for instance by producing bad-tasting compounds—so they can keep the meal to themselves.
We applied a novel weighted quantile sum approach to find the bad-actor compounds in the PCB mixture found in maternal serum.
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But other bad news has compounded the situation.
Ineptitude, poor equipment and bad information helped compound what initially seemed like a minor blaze.
The Knicks' 116-107 win at Madison Square Garden was the Lakers' season in a nutshell, compounding bad luck with bad timing.
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