The therapeutic response was defined as the combined clinical (no further antibiotic therapy was required) and bacteriological (original pathogens were erradicated) responses.
Mixed regression analysis was performed for the following outcomes: bacteriological cure, pathogen cure, clinical cure, postevent milk production and linear score, and survival to d 30 and 60.
First bacteriological cultures revealed uncommon pathogens like Staphylococcus lugdunensis and Bacteroides caccae.
According to Olayinka et al., constant bacteriological monitoring of the pathogens isolated from clinical specimens of patients in special units is necessary to draw attention of clinicians and infection control specialists to their current antibiotic susceptibility pattern and how often specific pathogens are isolated [ 10].
Therefore, the assay may (as with any standard bacteriological test) report the presence of pathogens in the absence of establishing a direct correlation with disease.
The reason for this association could be that farms with a higher ICM need to carry out more milk bacteriological tests to identify the causative pathogens.
Bacteriological culture to isolate the offending pathogen remains the mainstay of definitive diagnosis of septicaemia.
A bacteriological diagnosis was confirmed when a pathogen was isolated from an uncontaminated blood culture or sputum specimen obtained on admission.
The data comprised records of mastitis treatments and pathogen information (results of bacteriological culturing of milk samples) from Danish Holstein cows that calved for the first time between January 1998 and January 2009 (collection period).
Broad antibiotic therapy was initiated intraoperatively and was replaced by antibiotics specific to the pathogen once results of bacteriological analyses were available and continued during a mean of 4 months (range 45 to 360 days).
