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Clinical and bacteriological failure occurred for one of the 16 patients who had a confirmed infection.
The bacteriological failure rates of penicillins increased from 2 to 10% in the early 70's, but beginning in the late 70's, penicillin bacteriological failure rates increased to 30% in 2000's [39], maybe as the prevalence of β-lactamase production increased.
We changed the time definitions for the outcomes of clinical failure and bacteriological failure.
No bacteriological failure was documented after receiving empiric or consolidate antimicrobial regimen.
Clinical failure at follow-up was more common than bacteriological failure (75% versus 24%, p < 0.001).
Bacteriological failure occurred more frequently with doxycycline (RR 5.84, 95% CI 2.70 to 12.65, Analysis 13.5).
Similar(38)
That could lead to the risk of clinical and bacteriological failures as well as the emergence of bacterial resistance.
There were also more bacteriological failures with shorter treatment (RR 1.53, 95% CI 1.01 to 2.32, Analysis 15.6), although the trials were generally at high risk of bias, and underpowered to detect these effects so provide only low quality evidence of this effect.
Nonetheless, bacteriological treatment failure and sometimes clinical failure is well reported.
Bacteriological clearance and failure were defined as eradication or persistence, respectively, of COS gram-negative bacterial isolates on follow-up cultures, regardless of the clinical outcome of infection.
This allows for analysis of relation between treatment failure and bacteriological findings, as well as allowing for a sub study of antimicrobial effect of ibuprofen.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com