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At high ionic strength, substantial bactericidal potency was observed for the longer WWWWW tag down to KNK7-WWWWW.
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Truncating KNK10 from either C- or N-terminus results in a decrease in both bactericidal potency and salt resistance, although very short peptides are reached in both series (KNK5-WWW, KNK4-WWWWW, and KNG5-WWW, respectively) before significant reduction in bactericidal potency is observed at low ionic strength.
On the other hand, when the chlorine was placed at the para-position of 28, a recovery in potency was observed with an IC50 of 70 nM.
When the anti-HIV antibody b12 was tested as an IgA, IgM or IgG, equivalent neutralization potency was observed [14].
Upon di-substitution at phenyl ring, good enhancement in the potency was observed (compounds 5m, 5n and 5o).
A similar therapeutic potency was observed for the two compounds.
No androgenic (i.e. AR agonistic) potency was observed.
Optimal potency was observed with a 3-carbon chain (4).
No change was seen in AM2 potency for I52A, and a small reduction in potency was observed for G35A.
The best improvements in neutralizing potency were observed for the RSV neutralizing VHH, RSV-D3.
Similar differences in potency were observed in the BG1Luc4E2 cell line.
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