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The mechanism of increased bactericidal effect was studied by UV vis diffuse reflectance spectroscopy, photoluminescence spectroscopy, photocurrent response, and electrochemical impedance spectroscopy (EIS).
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In present study, a significant bactericidal effect was achieved in the opsonophagocytosis assay and the serum bactericidal assay (Fig. 5), indicating a phagocytosis and classical complement pathway killing mediated by the antiserum.
A 102 103 CFU bactericidal effect was also seen with HT61 but Mupirocin barely had any effect.
At this time, a complete bactericidal effect was observed.
The only exception was at 100% concentration, where bactericidal effect was observed.
However, the highest bactericidal effect was detected against S. aureus (MIC = MBC = 3.12 mg/mL).
Against other strains, reliable bactericidal effect was maintained at 4x MIC at 24 h after incubation.
An often cited criticism in advancing compounds to in vivo studies based on in vitro bactericidal effect is the lack of its predictive value.
The classic mechanism of defensins' bactericidal effect is the "pore formation" theory.
A bactericidal effect is desired because, to put it succinctly, dead bugs don't mutate.
Bacteria strains possessing the bactericidal effect were chosen to perform time-kill assay.
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