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The highest bactericidal effect was recorded for MRSA SA 3202 at 4x MIC at 24 h after incubation.
Results of artificial honey showed that all bacteria were inhibited at 50% (w/v) concentration and no bactericidal effect was recorded.
For the remaining strains, clinical isolates of MRSA SA 630, MRSA SA 3202, and S. aureus ATCC 29213, reliable bactericidal effect was recorded at 4x MIC at 24 h after incubation for all these strains with a reduction in bacterial count of 3.22, 3.30, and 3.65 log10 CFU/mL, respectively.
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Adverse effects were recorded.
A 102 103 CFU bactericidal effect was also seen with HT61 but Mupirocin barely had any effect.
The bactericidal effect was totally reversed in presence of isoleucine; leucine, valine and pantothenate indicated the specificity of antisense induction.
At this time, a complete bactericidal effect was observed.
The only exception was at 100% concentration, where bactericidal effect was observed.
However, the highest bactericidal effect was detected against S. aureus (MIC = MBC = 3.12 mg/mL).
Against other strains, reliable bactericidal effect was maintained at 4x MIC at 24 h after incubation.
In case of prolonged incubation time in the open wound, no bactericidal effect was reached (data not shown).
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