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In cases where no inhibitory or bactericidal effect was established for the respective extract or fraction, the results of respiratory activity were equivalent to untreated control and were therefore not shown in Table 1.
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A 102 103 CFU bactericidal effect was also seen with HT61 but Mupirocin barely had any effect.
The bactericidal effect was totally reversed in presence of isoleucine; leucine, valine and pantothenate indicated the specificity of antisense induction.
At this time, a complete bactericidal effect was observed.
The only exception was at 100% concentration, where bactericidal effect was observed.
However, the highest bactericidal effect was detected against S. aureus (MIC = MBC = 3.12 mg/mL).
Against other strains, reliable bactericidal effect was maintained at 4x MIC at 24 h after incubation.
In case of prolonged incubation time in the open wound, no bactericidal effect was reached (data not shown).
Additionally, our attempt to correlate a fingerprint analysis of the flux of various metabolites with bactericidal effect was also unsuccessful.
The classic mechanism of defensins' bactericidal effect is the "pore formation" theory.
A bactericidal effect is desired because, to put it succinctly, dead bugs don't mutate.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com