This finding could indicate that SBA lacks sensitivity (perhaps protection occurs before a titer of 1 8 is reached) or that protection rises through immune mechanisms other than the bactericidal combination of antibody and complement (such as osponophagocytosis).
We also demonstrated the bactericidal effect of a combination of a cranberry extract and β-lactams in vitro, and the therapeutic usefulness of such a synergistic combination of agents in a mouse mastitis model of infection.
In contrary, polymyxins + tigecycline was one of the promising bactericidal combination for our Singapore CR AB isolates, while polymyxins + carbapenem combination was not.
Subsequently, a further shortlist of bactericidal combinations were tested in vivo in a chronic model of tuberculosis in mice.
Similar to a drug discovery cascade, the in silico output is only the start of a combination discovery cascade, wherein the subsequent progression depends on the discovery of bactericidal combinations in vitro and, finally, bactericidal combinations in vivo.
To take advantage of this bactericidal effect, the combination of TO with an aminoglycoside such as TOB represents a new conceptual approach for treatment of CF patients who are frequently cocolonized by MRSA, S. aureus SCVs, and P. aeruginosa.
A total of 3 (15.0 %) of the drugs used in the farms contained a combination of an antimicrobial consider to be bacteriostatic with another consider to be bactericidal, 7 (35.0 %) of the drugs contained one or two antimicrobials consider as bactericidal while 10 (50.0 %) included one or two antimicrobials consider as bacteriostatic (Table 3).
Hence, our method of shortlisting based on growth inhibition was certainly more inclusive than exclusive in terms of identifying bactericidal combinations.
Treatment for serious enterococcal infections requires the combination of an aminoglycoside with β-lactams drugs such as penicillin/ampicillin for a synergistic bactericidal effect.
Our recent previous study reported the outstanding synergistic bactericidal activity of a combination of two natural antimicrobials: caprylic acid (CA) and citric acid (CTA).
