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Despite the striking similarity between the natural and synthetic nanostructured surfaces, some variations in bactericidal activity were observed among wings of different dragonfly species [2] and the biomimetic bSi surfaces [1].
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Maximum bactericidal activity was observed against Pseudomonas aeruginosa 3.
A strong bactericidal activity was observed against E. coli and P. vulgaris.
In time-kill curves no bactericidal activity was observed with any of the strains at concentration of 1MIC.
The compounds tested showed antibacterial activity (MICs of 8, 4/8 and 64/128 μg/mL to β-lapachone, 3-hydroxy β N lapachone and α-lapachone, respectively), but no bactericidal activity was observed (MBC > 512 μg/mL for all compounds).
Bactericidal activity was observed for eight bacterial strains at concentrations ranging from as low as 0.06 mg/ml for Corynebacterium diphtheriae to the maximal tested concentration of 120 mg/ml for E. faecalis (Table 5).> -wrap-foot> MIC - minimal inhibitory concentration; MBC - minimal bactericidal concentration.
When the combination COL + VAN was tested, bactericidal activity was observed after 2 h at concentrations of 0.5 × MIC COL (0.5 mg/L) + 0.25 × MIC VAN (32 mg/L) and 0.5 × MIC COL (0.5 mg/L) + 0.125 × MIC VAN (16 mg/L), which was maintained until 24 h (Fig. 2a).
On the other hand, antibacterial activity was observed when graphene coated the copper substrates, resulting from the release of bactericidal cupric ions in inverse proportion to the graphene surface coverage.
As shown in Figure 4, both the compounds revealed increased activity at acidic pH (pH-4.0) and a dose dependant bactericidal activity was also observed.
Photographs of handwash solutions and bactericidal activity were showed in Figure 4.
Neutrophil functions, chemotaxis, chemokinesis, adhesion and bactericidal activity were unaffected by n-3 LCPUFA supplementation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com