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Bactericidal activity was tested against each bacteria identified from the burn wound.
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In Phase 1, the ability of a product to demonstrate bactericidal, fungicidal or sporicidal activity is tested.
When the combination COL + VAN was tested, bactericidal activity was observed after 2 h at concentrations of 0.5 × MIC COL (0.5 mg/L) + 0.25 × MIC VAN (32 mg/L) and 0.5 × MIC COL (0.5 mg/L) + 0.125 × MIC VAN (16 mg/L), which was maintained until 24 h (Fig. 2a).
To test whether this bactericidal activity was due to HCO3−, the cells were pretreated with carbonic anhydrase inhibitor, acetazolamide (50 µM), and it was found that the bactericidal capacity of the culture was greatly attenuated (Figure 4C).
The bactericidal test results of this study, defined by MBCs, showed that vancomycin bactericidal activity was not inferior to that of oxacillin and teicoplanin against MSSA.
Serum bactericidal activity was measured with human complement.
The coating bactericidal activity was initially strong.
Maximum bactericidal activity was observed against Pseudomonas aeruginosa 3.
The bactericidal activity was carried out using well diffusion method.
A strong bactericidal activity was observed against E. coli and P. vulgaris.
Interestingly, bactericidal activity was only exhibited by antibodies against linear peptides.
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