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Perhaps a cocktail of several phage strains will be necessary for controlling bacterial variation.
Since its initial introduction (Maiden et al. 1998), MLST has been embraced for characterizing bacterial variation and facilitating epidemiological investigations (Maiden 2006).
Further research is needed to explore why the occurrence and type of EPTB differs by region of birth and whether host genetic and/or bacterial variation can explain these differences in EPTB.
Early studies on bacterial variation singled out a distinguishable property (such as motility) in order to sort bacteria into subpopulations [ 19]; however, not all biological traits are easily distinguishable or easy to use as filtering criteria.
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Although the link between antibiotic exposure and bacterial sequence variation in genes such as gyrB and recA has been established, evidence for the role of sequence variation in genes such as dnaN and dnaH antibiotic treatment is scanty.
A fuller understanding of bacterial genomic variation could provide insight into host pathophysiology.
See Methods section for details. Figure 1: Representation and analysis of bacterial genetic variation.
Jolley, K. A. & Maiden, M. C. BIGSdb: scalable analysis of bacterial genome variation at the population level.
We previously demonstrated that P. didemni synthesizes cyanobactin secondary metabolites isolated from whole ascidians and that bacterial strain variation underlies the varied "ascidian" natural products (Figure 1) [15] [16], [17], [17].
Among X. bovienii bacterial strains, variation in NRPS and PKS coding potential also occurs (Table 3).
The broad range of disease severity may be influenced by bacterial genetic variation.
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