Pathway enrichment analysis identified several interesting pathways including the GABA receptor activation pathway.
These pathways include: the bacterial secretion system, two-component system, β-lactam resistance, and cationic antimicrobial peptide pathways.
The other 12 pathways include the ErbB signaling pathway, prolactin signaling pathway, oxytocin signaling pathway, insulin signaling pathway, sphingolipid signaling pathway, neurotrophin signaling pathway, GnRH signaling pathway, cholinergic synapse, Jak-STAT signaling pathway, inflammatory mediator regulation of TRP channels, estrogen signaling pathway and AMPK signaling pathway.
In OLpres, these pathways included the cytochrome P450 pathway.
Altogether, our results strongly indicate that the dramatic toxic effect of potassium tellurite in E. coli can be associated with the chemical activity of the tellurium oxyanion at various levels of bacterial metabolic pathways including, among others, inactivation of [Fe-S] center-containing dehydratases, cytoplasmic thiol oxidation, enzyme and protein carbonylation and membrane peroxidation.
The different types of assays targeting classical bacterial functions and essential pathways, including DNA replication, cell wall biosynthesis, and protein biosynthesis, have been extensively described in recent papers [ 63, 64].
We have recently demonstrated that cellular invasion with Salmonella triggered an acute and transient state of amino acid (AA) starvation, which altered mTOR sub-cellular localization and activity, thereby impacting on host defense pathways, including anti-bacterial autophagy (Tattoli et al., 2012).
EFEMP1 acts via multiple signaling pathways, including γ-secretase-mediated activation of the Notch pathway.
The insulin-signaling pathway activates a powerful gene regulator that controls many genetic pathways, including some that govern metabolism.
The biosynthesis of fatty acids is another pathway essential for bacterial survival and includes the previously described FASII pathway, which is also considered an important target for anti-TB drug discovery [ 65].
