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Growth of a microorganism in a host is essential for infection, and bacterial pathogens have evolved to utilize specific metabolites to enhance replication in vivo.
Moreover, many bacterial pathogens have evolved cell cell communication (quorum-sensing) mechanisms to mount population-density-dependent attacks to overwhelm the host's defense responses.
However, successful intracellular bacterial pathogens have evolved diverse mechanisms not only to suppress the IFNγ production by T cells, but also to down-regulate the responsiveness of macrophages to this cytokine17.
In transition from extracellular environment to their mammalian host, bacterial pathogens have evolved complex adaptation mechanisms to promote their survival and multiplication.
Therefore, bacterial pathogens have evolved the capacities to directly hijack host phosphorylation or ubiquitination machineries in order to promote their survival in the host (Galan and Wolf-Watz, 2006).
We hope to gain a better understanding of how bacterial pathogens have evolved to recognize and evade host cellular processes.
Similar(42)
Indeed, such subversion occurs at nearly all points of the apoptotic cascade with different bacterial pathogens having evolved distinct modes to induce or inhibit specific apoptotic pathways in an attempt to manipulate the lifespan of infected cells and/or influence their behaviour in a manner that supports infection.
Many pathogens have evolved to elude immunity and this has limited the utility of current therapies.
Most pathogens have evolved variants that are able to express non-uniform surface structures.
However, many pathogens have evolved methods to evade attacks by phagocytes.
Pathogens have evolved to disrupt this critical process and thereby evade the host response.
More suggestions(16)
bacterial pathogens have adopted
bacterial phylotypes have evolved
bacterial genomes have evolved
bacterial pathogens have become
bacterial Prxs have evolved
bacterial populations have evolved
bacterial pathogens have co-evolved
bacterial strains have evolved
bacterial pathogens have been
bacterial ProRSs have evolved
bacterial proteins have evolved
bacterial pathogens have emerged
bacterial pathogens have given
bacterial pathogens have identified
bacterial cells have evolved
bacterial species have evolved
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com