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● To our knowledge, this is the first trial to investigate the potential effects of gut bacterial modulation on advanced glycation.
Recently, a novel approach has been described through bacterial modulation of the dose-limiting side effect of the common colon cancer chemotherapeutic CPT-11.
Since NO donation can enhance cystine transport across mammalian cell membranes (55), it is conceivable that bacterial modulation of NO concentration results in selective loss of SNO-associated amino acids (i.e., S-nitroso- l-cysteine).
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We provide novel information about bacterial enzymatic modulation of the IgG/FcγR interaction that emphasizes the importance of glycosylation for antibody effector functions.
Understanding the mechanisms of bacterial immune modulation will teach us more about pathogenesis of infection and could lead to new strategies in anti-inflammatory therapy during sepsis.
However, the strategies for bacterial electrochemical activity modulation are still limited.
The inhibition of drug transporters is one form of modulation bacterial resistance to antimicrobial drugs [ 21].
Its effect is mediated through: enhanced phagocytosis as evidenced by increase of oxidant stress and decrease of tissue bacterial load; and modulation of inflammation as evidenced by increase of apoptosis of monocytes.
Because proinflammatory responses play an important role in the pathogenesis of bacterial meningitis, their modulation may be an important component in the disease management (for review, see the report by Tauber and Moser [ 10]).
Goh, E. B. et al. Transcriptional modulation of bacterial gene expression by subinhibitory concentrations of antibiotics.
Kaparakis-Liaskos, M. & Ferrero, R. L. Immune modulation by bacterial outer membrane vesicles.
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