In animal models, broad-spectrum antibiotics reduce the bacterial load and militate against intestinal inflammation.
Notably, the high bacterial load and various proteases in CF sputum, extraction methods, and storage could affect metabolites.
Common tests include stool tests for malabsorption and inflammation, blood tests for inflammation, breath hydrogen test to assess bacterial load and nutrient and essential fatty acid deficiencies.
Bacterial load and lung PA correlated relatively weakly but significantly (Figure 4B).
Bacterial load and P. melaninogenica assays were performed on all samples (n = 432 sample measurements).
The severely impaired dissemination may limit a quick expansion of the total bacterial load and thus affects the immune response.
At this time point HFD-fed mice have increased bacterial load and their mortality starts to increase.
CF airways inflammation appears excessive and prolonged in regard to bacterial load and associated with large numbers of neutrophils.
It appears that bacterial diversity, bacterial load and the extent of tissue infiltration in combination with the maternal response to the bacteria may be important.
We found that AnxA5 significantly reduced the number of large inclusions in MF, indicative for reduced bacterial load and replicative activity (Fig. 6C, p = 0.02).
Importantly, splenomegaly persisted beyond the presence of measurable CFU of S. Typhimurium, and splenic bacterial load and splenomegaly correlated with the most severe cytopenias.
