Our 2D-DIGE-based discovery approach revealed an imbalance of intestinal bacterial functions in CD.
These results provide an oral biofilm model and show that in vivo observations on biofilm architecture are an essential link between molecular diversity and bacterial function in relation to oral diseases.
Reg3a, Reg3b and Reg3g are also involved in anti-bacterial function in intestinal epithelial cells [ 60] and could be involved in repairing AMPH-induced damage in the MAV.
Ca++ is implicated in a number of bacterial functions, including chemotaxis and the cell-cycle [12], [13].
Iron acquisition in vivo is an important bacterial function and in pathogenic bacteria, iron-limitation is often a signal for the induction of virulence genes.
Transcriptional regulators play crucial roles in bacterial functions and they have been classified into a number of families [ 81].
Overall, however, we found little evidence of major detrimental long-term effects of tillage on the soil bacterial communities or their important functions in the dryland wheat system studied.
ADI1 encodes a protein with homology to bacterial aci-reductone dioxygenase, which functions in the methionine recycling pathway.
With the decreasing cost of metagenome sequencing and development of techniques for culturing and for functional studies of gut bacteria, we expect to learn more about the levels of bacterial genes, metabolic pathways, and their functions in the future.
Transposon mutagenesis has been used to identify genes involved in pathogenesis and other bacterial functions [ 14- 18].
