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Bacterial counts in arterial and portal venous blood were analyzed hourly during the E. coli infusion, and were corrected for the bacterial dose administered per body weight.
The improved response, which was dependent on the bacterial dose used, was observed in terms of stronger inhibition of tumor growth as well as enhanced host survival.
Although the researchers injected less than 1% of the bacterial dose the dogs had received into the shoulder metastasis, the growth began to dwindle.
The cavities, Seiler said in his talk, confirm that the Iceman ate a diet abounding in carbohydrates, such as bread or cereal, and reveal that he possessed a "heavy bacterial dose on these teeth".
Colonization of lymph nodes was independent of the type I IFN signaling, as well as bacterial dose and strain.
These observations suggested that lymph node colonization by L. monocytogenes with subsequent IFN-β production is general phenomenon and does not depend on the bacterial dose, strain or type I IFN signaling.
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Some flies were colonized while others remained germ-free even at extremely high bacterial doses.
In this work, we evaluated the evolution of experimental tuberculosis in mice infected with increasing bacterial doses or via distinct routes.
We showed that mice infected with low bacterial doses by the intratracheal route were able to develop a progressive infection that was proportional to the inoculum size.
Significant IL-10 concentrations and a more preeminent T regulatory cell recruitment were also detected at 70 days post-infection with high bacterial doses.
At all bacterial doses, WT mice showed very low mortality at 72 hours post-implantation (PI).
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