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We now have the capacity to address previously intractable questions regarding bacterial diversification during infection which will ultimately lead to enhanced understanding of pathogenesis and the nature of epidemics, and will inform the design of effective therapeutic measures.
As such, T4SSs are important factors in bacterial diversification and are responsible for the lateral mobilization of antimicrobial resistance and virulence genes.
Given the importance of Roseobacters in biogeochemical cycles of the ocean, their well-characterized genome sequences [6] within a clade, and global abundance, the marine Roseobacter clade is ideal for elucidating bacterial diversification and adaptation to ocean environments.
Mobile genetic elements (MGEs) and genetic rearrangement are considered as major driving forces of bacterial diversification.
To clarify bacterial diversification mechanisms, there are several genetic factors to be considered.
Therefore, we concluded that these conventional methods are insufficient for understanding bacterial diversification or evolutional traits.
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Using longitudinal samples collected form a subset of these patients a pattern of initial bacterial community diversification was observed in younger patients compared with a progressive loss of diversity over time in older patients.
This process plays an important role in DNA repair as well as bacterial genome diversification.
This work improves our understanding of the process responsible for bacterial genome diversification and evolution.
Phages, prophages and transposons functions can play a role in bacterial genome diversification [ 29].
Indeed, the biofilm mode of growth has been shown to play an important role in the evolution of bacterial phenotypic diversification, which is commonly associated with specialized adaptation to the different compartments in the CF airways [ 24, 25].
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