As virulence regulators have recently been found to control bacterial cell cycle transcription (Fumeaux et al., 2014), capsulation might also be regulated by the cell cycle.
Cumulatively, this study uncovered novel new layers of transcriptional regulation mediating the bacterial cell cycle.
Sobetzko, P., Travers, A. & Muskhelishvili, G. Gene order and chromosome dynamics coordinate spatiotemporal gene expression during the bacterial growth cycle.
The bacterial cell cycle regulator GcrA is a σ70 cofactor that drives gene expression from a subset of methylated promoters.
During the bacterial division cycle, cell wall synthesis and remodeling are coordinated with membrane constriction, led by the tubulin homologue FtsZ.
Macheboeuf, P., Contreras-Martel, C., Job, V., Dideberg, O. & Dessen, A. Penicillin binding proteins: key players in bacterial cell cycle and drug resistance processes.
The Lyme Multiplex assay quantifies antibodies directed against specific proteins on the surface of B. burgdorferi at three different stages of the bacterial life cycle.
Although her proposed research was met with skepticism, Shapiro explained that she persevered and her investigations revealed how the bacterium Caulobacter crescentus works, creating a model organism that provides insight into the bacterial cell cycle and more.
Our findings have implications for our understanding of membrane biology, bacterial cell cycle control and potentially for the design of antibiotics that target the cell membrane.
Further analysis revealed that nGO-PEG (1 1) treatment significantly accelerated FtsZ-ring assembly, shortening Phase 1 in the bacterial cell cycle.
