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Muramyl dipeptide (MDP) – an essential bacterial cell wall component – is recognized by our immune system as pathogen-associated molecular pattern (PAMP) which results in immune responses with adverse toxic effects.
LPS is a gram negative bacterial cell wall component and a TLR4 ligand [8], [9].
In addition to these lipoproteins, TLR2 also recognizes and responds to the Gram-positive bacterial cell wall component, lipoteichoic acid (LTA) [10].
Of note, BPI and LBP play well characterized roles in sensing and responding to Gram negative bacteria, mediated primarily through their ability to bind the Lipid A region of the bacterial cell wall component lipopolysaccharide [19].
LPS is a bacterial cell wall component known to act as a macrophage activator [ 23].
NOD2 is an innate immune receptor for the bacterial cell wall component muramyl-dipeptide.
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Takeuchi O, Hoshino K, Kawai T et al. Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components.
The positive charge of AMPs presumably enables interactions with the negatively charged outer leaflet of bacterial membranes and/or bacterial cell wall components, whereas their amphipathic character causes membrane permeabilization (Devine and Hancock 2002; Teixeira et al. 2012).
For example, TLR2 and TLR4 are implicated in the recognition of various bacterial cell wall components such as lipopolysaccharide, lipoproteins and glycolipids [25].
It is noteworthy that characterization of TLRs showed unresponsiveness of our HT-29 and Caco-2 reporter cells toward agonists of the bacterial cell wall components receptors TLR1/2, TLR2 and TLR6/2.
They express TLRs 1, 2, 3, 4, 5, 6, and 8 resulting in their ability to respond to stimulation with bacterial cell wall components and viral RNA [9], [10].
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