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Farmers and ranchers feed small amounts of the drugs to animals over their lifetimes to keep them healthy in crowded conditions, causing bacteria to develop a resistance passed on to people through the environment and eating meat from the animals.
Part of the reason these bugs spread so rapidly often comes down to mis-use of antibiotics, leading the bacteria to develop a resistance to the drugs available.
By interfering with such a critical cellular process in such a fundamental way, vancomycin makes it hard for bacteria to develop a simple mutation to defeat the antibiotic.
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It would be unrealistic, he argued, to expect the targeted bacteria to develop such a profound adaptation by natural selection, or by borrowing the DNA for such a defense from other microbes.
It took about 30 years for bacteria to develop resistance to a similarly acting antibiotic, the study noted.
As a starting point for this research, we exploited the ability of bacteria to develop metal resistance as a microbial biomarker.
Multiple antibiotics are given to reduce the ability of the bacteria to develop resistance.
In addition, their unwarranted use helps drug-resistant bacteria to develop, the authors said.
Profligate use of antibiotics has provided the evolutionary driver for bacteria to develop resistance to the drugs.
"Because of how they work, some antibiotics are just harder for bacteria to develop resistance against," he says.
These are ancient natural chemicals, so they're hoping it'll be tough for bacteria to develop resistance to them.
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