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Bacteria from the lean mice made their way to the mice with the obese twin's bacteria, preventing those mice from gaining weight and developing other metabolic abnormalities.
That led to the discovery that bacteria from the lean twins took over in the mice that started out with bacteria from the fat twins, resulting in weight loss and a correction of the metabolic abnormalities the mice had developed.
In the latest study scientists isolated gut bacteria from identical and non-identical twins, where one sibling was obese and the other was lean, and found that the bacteria caused mice to become lean or overweight depending on whether they received the bacteria from the lean or obese twin respectively.
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The investigators discovered that given a chance, and in the presence of a low-fat diet, bacteria from a lean twin will take over the gut of a mouse that already had bacteria from a fat twin.
The researchers put mice with gut bacteria from lean twins in the same cage as mice with gut bacteria from obese twins.
In the 2 August 2005 Proceedings of the National Academy of Sciences, Ley and other researchers led by Jeffrey Gordon, director of the Center for Genome Sciences at Washington University, found that the gut microbiota of genetically obese mice contained a high percentage of bacteria from the phylum Firmicutes whereas their lean littermates had more bacteria from the phylum Bacteriodetes.
They transferred samples of the gut bacteria from obese and lean mice into two groups of microbiota-free mice.
Mice carrying gut bacteria from lean humans protect their cage mates from the effects of gut bacteria from fat humans.
The mice who got microbes from the lean twins stayed lean, the researchers report today in Science.
Lean production is a system that ought to be distinguished from the lean characterizing elements and manifestations that Sugimori et al. (1977) originally described.
This bacteria is coming from sewage runoff from both cities and farms, meaning it contains bacteria from the stomachs of humans and animals.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com