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This is because the bidirectional search algorithm (feature selection method) obtains a set of representative features that is achieved by iteratively applying sequential forward and backward selections to select good and remove bad features from the feature set, and further provides a solution that is close to optimal.
To overcome this problem we have devised a primal SVM method with the following properties: (1) it solves for the SVM representation without the need to invoke the representer theorem, (2) forward and backward selections are combined to approach the final globally optimal solution, and (3) a criterion is introduced for identification of support vectors leading to a much reduced support vector set.
Both forward and backward selections were used to find the most appropriate model.
Variables that showed significant differences in univariate analysis (P < 0.05) were the candidate predictor variables for the stepwise logistic regression analysis including both forward and backward selections.
Figure 3 summarizes the general framework applied in subchallenge 1. Sequential forward and backward selections are combined to implement the bidirectional search algorithm.
The bidirectional search algorithm finds a near-optimal set of features to predict the response of the cells to the drugs by combining the merits of sequential forward and backward selections.
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Information seeking and deliberation were selected by backward selection only.
** Regional variables were selected using backward selection based on Wald test, p-values > 0.1.
= not selected by stepwise regression Stepwise regression (backward selection) of HSV-2 serostatus on selected covariables.
All covariates were selected using a backward selection (p<.05 to stay).
Important interactions were selected through stepwise backward selection (P<0.05).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com