The possible microstructural background responsible for the 4-times improved polarization was discussed.
Several SNPs in these genes are related to alteration of enzymatic activity, and genotypization can thus contribute to define a specific metabolic background responsible for the drug's efficacy.
The possibility to define a specific metabolic background responsible for drug's efficacy (triptans) in migraine could reduce the use (misuse → abuse) of such drugs in a pre-defined nonresponders' population of migraine patients, avoiding one of the most important factors in the chronicization progress towards CM, such as triptans abuse.
Currently, several panels of tetravalent DEN vaccine candidates have been derived from viruses of diverse genetic background responsible for growth restriction [13], [16].
This backcross should represent a good opportunity to identify modifier genes in the C57B1/6 genetic background responsible for the phenotype changes.
A presumptive ATP-binding region is located at the N-terminal pole of the TK domain and contains a conserved lysine (K606, Figure 7, black background) responsible for binding ATP.
Among SA isolates, clones with distinctive genetic backgrounds are responsible for the majority of infections within a host type, although the distinct bovine clone groups are often interspersed among the human clone groups in a manner suggesting that human-associated SA clones were the evolutionary precursors to modern bovine specialist SA clones [11], [13], [15], [16].
In support of the view that the increased levels of E-cad in core pathway mutant backgrounds are responsible for the intercalation defect, we found that the dsh phenotype was suppressed by a reduction in E-cad gene dosage (Fig. 2G).
If genetic background is responsible for the increased pathogenicity towards wax moth observed in the color mutants in the B5233 background, then a different virulence pattern would be expected for color mutants in the Af293 background.
To test whether epistatic interactions between genes on the wild-derived chromosomes and the mthR3 background were responsible for the failures to complement, we used an F-statistic to examine the equivalency of variances in both the mth wild-type and mutant backgrounds [31].
