Despite differences in genetic backgrounds, altered expression of miRNAs correlated with altered expression of ~70% of their candidate target genes, and in all cases miRNA overexpression affected post-mating oviposition.
Therefore, current attempts to establish the construct validity of various RTT mouse models (e.g. null versus point mutations) would benefit from detailed comparisons of how the corresponding alleles, when studied in the same genetic background, alter target gene expression, cell physiology and neurological function.
Although genetic background altered the expression of thousands of transcripts, only 41 GO terms (20 CCs + 21 MFs, Table S4) were enriched with such transcripts, which suggested the strain signature transcripts were relatively evenly distributed across GO terms.
Our aim was to assess how variation in cell line backgrounds alters the effects of p53 loss.
"It's easy enough to add filters to an image, or overlay seasonal clipart, but when you want to change a background, or alter your hair colour, most people need professional help".
To determine whether genetic background might alter the physiological actions of the TP receptor, we studied two lines of TP knockout (Tp-/) mice with distinct genetic backgrounds (C57BL/6 and BALB/c).
Our results raise the possibility that H. pylori infection and other Th-1 modifying infections present in the host background can alter these profiles.
Variability in mitochondrial genetic background can alter reactive oxygen species production, leading to cancer risk.
This epistatic influence manifested such that the cytoplasmic background could alter or hide pairwise epistasis between nuclear loci.
As we found no effect of CR on rDNA silencing, we investigated whether deletion mutations that reproducibly extend lifespan in multiple yeast background strains alter rDNA silencing.
