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Male heterozygous Coq9 Q95X/ + mice (C57BL/6N genetic background) were crossbred with female Coq9+/+ mice under C57BL/6J genetic background.
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Cbs+/− and Tg 152F7 mice, on the same background, were crossbred.
To obtain mouse embryonic fibroblasts (MEFs), mice heterozygous for the OREBP alleles (OREBP+/−) on a SVJ129/C57BL/6N background were crossbred [38].
Hemizygous 5XFAD transgenic mice (B6/SJL hybrid background) were crossbred to BACE1 homozygous knockout (BACE1−/−) mice (C57BL/6 background, The Jackson Laboratory, Bar Harbor, ME) [10], [59] or C57BL/6 control mice.
Heterozygous transgenic 5XFAD mice (B6/SJL hybrid background) were crossbred to Gulo KO mice.
After the chimeric mice were made, they were crossbred with Cre-transgenic mice (CD-1 background) that transiently express Cre recombinase in eggs [28].
Transgenic hemizygous SOD1-G93A males were crossbred with C57BL/6 females, both maintained on the C57BL/6 genetic background.
In 19th century Normandy, native mares were crossbred with Thoroughbred or Norfolk Trotter stallions.
Many horses were crossbred with draft horses, and the breed almost became extinct.
The Finnish horses in these now-Russian areas were crossbred with the Russian horses in significant numbers.
In the late 18th century, imported horses from the US and the British Isles were crossbred with existing Canadian stock.
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