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By accounting for the background set of polymorphisms on which a trajectory develops, the linked method corrects for clonal interference, which can reduce apparent selection coefficients, and, through recognition of fixation events occurring through hitchhiking with driver alleles, assigns lower selection coefficients to passenger loci at which the mutant allele reaches fixation.
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The hypergeometric distribution was used to assess enrichment between the background set of probe-sets and a sample set.
We also needed to construct a background set of non-pre-miRNA hairpins to estimate the background noise.
The set of polymorphisms reduced to 12,508 putatively neutral 100 bp loci.
Our background set consists of 1000 sequences also from dbTSS.
Background set used was the entire set of known mouse genes.
The background set was defined as the drug sets of two dissimilar ADRs.
We used the entire set of core genes as our background set.
The background set was constructed from all S/T centered 9-aa peptides extracted from proteins of the background protein set excluding those known as phosphorylation sites.
Get your background set up.
Each gene was tested for a comprehensive set of single-nucleotide polymorphisms (SNPs).
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CEO of Professional Science Editing for Scientists @ prosciediting.com