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In this study almost all analysed cis-elements were normally (or near normally) distributed in the background population, generated by the applied randomization algorithm.
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SOD1G93A mice on a B6 background were generated by crossing B6SJL-TgN SOD1-G93A 1Gur males (Jackson Laboratory) to B6 females for 4 7 generations (N4 N7), and then SOD1G93A mice on an Als2-null background were generated in a similar manner.
Background noise generated by mastication was substantially attenuated by the selectable reference circuit.
Creb1loxP/loxP mice on a C57Bl/6 genetic background were generated by gene-targeting as described previously [12].
The dmpk−/+ heterozygous mice on 129SV background were generated by Reddy et al. [13].
WT, and PRLR KO mice on a pure 129 genetic background were generated by heterozygous crossbreeding [19].
Parp1−/− mutant mice under a B6D2F1 hybrid background were generated by sequential backcrosses of Parp1+/− mice to C57BL/6J and DBA2/J [11].
Background signals generated by the cell-free media were recorded.
Tie2- Scarb1 and LIV11- SCARB1 double transgenic mice on a Scarb1-KO background were generated by crossing.
C3-deficient mice (C3-/) on a C57bl/6 background were generated by Professor M Botto [ 18].
PKD2-knockin mice on a C57BL/6 background were generated by Ozgene.
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