Sentence examples for background of wild type from inspiring English sources

The fact that these forms cause lethality in the background of wild type endogenous Lamin C suggests they are functioning in a dominant negative manner.

As controls for the experiments, similar single-cysteine substituted mutants at amino acid positions 107 135 were generated on the background of wild type (WT) rhodopsin, containing the six natural cystein residues, which are labeled as P107C R135C/WT.

Single NTERA2.Tom cells were seeded with a background of wild type NTERA2 cells at a density that permits neuronal differentiation (15000 cells/cm2), and induced to differentiate by the addition of RA.

In the study herein, the level of mutant p53 molecules (within a background of wild type p53 molecules) in four of the six plasma samples was very low (Table 2) and would not be detectable by most of the common methods of analysis.

We begin with a system composed of 10% mutant cells in a background of wild type.

Furthermore, increasing evidence suggests that even in tumors with EGFR mutations only a fraction of cells carry the mutant alleles that will be therefore diluted in a large background of wild type DNA [ 15].

All data were normalized using the intrinsic background intensity of wild type embryos at each embryonic stage.

However methodologies to analyse the presence of rare mutations in a background of wild-type DNA requires a detailed assessment.

However, most existing methods for the detection of low-level DNA mutations are insufficient for clinical applications because of the high background of wild-type DNA.

This probe was able to differentiate the intended mutation in a sample containing as little as 5% mutant alleles in a background of wild-type DNA.

Another application for ARMS-DCA results from its ability to selectively amplify rare mutant alleles in a background of wild-type sequences, a feature being of paramount importance in cancer screening.