Our tissue-specific selection of differentially methylated probes was important to identify concerted changes in average methylation levels that occur on top of the epigenetic background of tissue-specific repressive events.
These findings suggest that the oncogenic background of tissues in which DIAPH3 is lost makes an essential contribution to tumour behaviour.
In addition, using human kidney biopsy samples from a nephropathy patient, IgA depositions in glomeruli could be detected by immunohistochemistry with low background staining of tissue.
This occurs alone as primary SS (pSS), or against a background of connective tissue disease as secondary SS (sSS).
This method is well suited for detection of somatic mutations, which may be present in a small fraction of tumour cells within a background of normal tissue.
Subtle changes in gene expression could be imaged here even when they occurred above elevated background expression rather than the completely dark background of inactive tissue, as shown by logarithmic scaling.
We detected extracellular iron, including ferrous iron, especially in active lesions of aged patients with acute MS and short disease duration, where new active lesions form against the background of high tissue iron load.
The observation of chronic peri-aortic infiltrates, consisting mainly of lymphocytes, monocytes, plasma cells, and sparse mast cells, usually on a background of fibrous tissue, has prompted use of the term 'inflammatory AAA' and retroperitoneal fibrosis as a distinct clinical entity, and the concept of an adventitial shift from innate to adaptive immunity in AAAs.
In this case, while there were still 123 virulence genes from other taxa associated with the tumor microbiome, the enrichment is not significant compared with the background of normal tissue from the same cancer patients (Fisher's exact test one-sided p value >0.9).
Upon injection of luciferin, bioluminescent background of normal tissues in the transgenic mice and bioluminescent signals from spontaneously mammary carcinomas were measured non-invasively with an IVIS Spectrum imaging station.
The detected displacement in the background of the tissue-mimicking phantom was around 5 μm.
