This could be either specific to the genetic background of the cell lines used or due to different experimental approaches.
Information regarding the genetic background of these cell lines is available online at the ATCC website.
Firstly, whole-genome sequencing is used to determine the genetic background of the cell line.
The genetic background of the cell lines might play a role in the observed variation.
Due to the shared genetic background of the cells, our rationale was that the differential expression of miRNAs would correlate well with their differential aggressive phenotype.
Differentially regulated genes in 3Amut LCLs and 3BKO LCLs were identified using an ANOVA model including the donor ID (for genetic background of the cells).
These different responses may be due to the divergent genetic background of these cells.
Inhibitory effects of CIP2A downregulation on proliferation of melanoma cells were not related to the genetic background of the cells.
Although the reasons for this dissimilarity are not yet clear, the inconsistency could be caused by differences in the genetic background of the cells.
Autophagy may precede apoptosis or be induced simultaneously depending on the genetic context and cellular background of the cells.
