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The success of such a procedure will depend on the genetic background of the respective cancer cells.
Within each fragment, amplitudes of peaks were estimated by summing the values (log2 signal vs. background) of the respective probes.
The RTK pathway intersection the authors observed in MEPM cells could easily be thoroughly validated in the background of the respective mutants.
Cell context-dependent differences exist in the mechanisms of cell death, which may be related to the genetic background of the respective cell lines, such as the differences in p53 status, but cell death was observed in either case.
Although the pathophysiological background of the respective mutations has to be further investigated, amplicon deep-sequencing assays may identify new prognostic parameters and contribute to more diversified therapeutic concepts, for example, by investigation of compounds targeting the RAS pathway in subsets of myeloma patients.
In contrast to traditional research in philosophical ethics, additional issues should be considered here which pertain to pragmatic aspects of conducting the research, as well as to more theoretical facets, such as the interrelation between the ethical-theoretical and the socio-theoretical background of the respective study.
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The genetic relatedness of these small bats to the largest form in Libya suggests an unexpected degree of phenotypic plasticity in these bats, apparently driven by temporary local conditions rather than by the genotypic backgrounds of the respective populations.
Background information of the respective strains examined is described in the supplementary Table S1.
The GFP fluorescence in medium was obtained by subtraction of the background fluorescence of the respective samples from GFP-negative Jurkat cultures.
DNA enriched by the antibody IgG served as negative control and background level of the respective assay.
Telomere length was calculated by the mean telomere spot intensity with mean background subtraction of the respective nucleus on maximum projection images.
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